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For example, in the MIRI model, the initiation of the ATF4-C/EBP homologous protein (CHOP) pathway can trigger ERS and promote ferroptosis ( Recent studies have found that inflammation significantly contributes to MIRI induced by ferroptosis

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The distinct configuration of the GAMEN motif in IRAP generates additional space around residues 3 and 4 of the bound linear peptide, which could be used for the accommodation of bulkier side chains, possibly affording a broader selectivity for peptides

Devanaboyina, S

Xiao et al., 2021)

Manganese is essential centrations in rheumatoid arthritis: Influence of for normal insulin synthesis and secretion by dietary factors and disease activity