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146,147,148,149 The CRISPR-mediated gene-editing system primarily involves Cas9 and single guide RNA (sgRNA) to introduce DNA double-strand breaks (DSBs) at specific positions in the genome

Specifically, a positive correlation was observed between pain magnification and the neurometabolites Gln and Glx, as well as the near-significant neurometabolites NAA and NAA + NAAG (Figure 3 and Supplementary Table 3)

Our research revealed that estrogen/ER signaling inhibits ferroptosis in ER+ breast cancer by upregulating the expression of SLC7A11 and SLC3A2

Unlike normal cells obtaining energy through oxidative phosphorylation (OXPHOS), cancer cells preferentially convert pyruvate, the end product of glycolysis, into lactate rather than directing it into mitochondrial for O 2 -dependent metabolism even in the presence of oxygen, which is the Warburg effect, the most classic example of metabolic reprogramming in cancer [190]

A meta-analysis was conducted by combining the results from the two cohorts