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4.4.2 Function of curcumin in HD Although multiple cellular events, including oxidative stress, mitochondrial dysfunction, neuroinflammation and transcriptional dysregulation, have been identified in HD, the development of effective therapies with favorable safety profiles remains an unmet medical need (Elifani et al., 2016)

Murdoch GH, Potter E, Nicolaisen AK, Evans RM, Rosenfeld MG

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Erythema occurs in a majority of patients receiving methylphenidate as the transdermal system but generally causes minimal or no discomfort