acetaminophen toxicity glutathione Reducing the effects of drug on metabolism Too much paracetamol = dangerous
Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products Acetaminophen Toxicity and Liver Zone Physiology [#DaVinciCases GI 5 Physiology Case 3] Acetaminophen toxicity EMCrit Project
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