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The present invention encompasses the addition of a nuclear localization signal, operably linked to the 5 end, 3 end, or any location therein, to any of the oligonucleotides, antisense oligonucleotides, triple helix oligonucleotides, ribozymes, PNA oligonucleotides, and/or polynucleotides, of the present invention

Al, obese Zucker rats were received a dose of 500 micrograms/kg of body weight over the course of 19 days

J Lipid Res 50:15091520 Ilyin SE, Belkowski SM, Plata-Salamn CR (2004) Biomarker discovery and validation: technologies and integrative approaches

A phase III, randomized, placebo-controlled, double-blind trial of flaxseed for the treatment of hot flashes: North Central Cancer Treatment Group N08C7