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Description

The enzyme dipeptidyl peptidase 4 (DPP-4) cleaves active GLP-1 (7-36) amide and (7-37) non-amide after secretion from the gut and brain, forming two GLP-1 metabolites 8,10,12,13

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In summary, GABAergic system dysregulation represents a central mechanism in ASD pathophysiology, offering both theoretical insights and therapeutic opportunities