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Furthermore, the aging ECM, enriched with degradation products and inflammatory factors, combined with oxidative stress, compromises nitric oxide (NO) bioavailability, impairing NO-mediated vasodilation and blood nutrient supply 134

Alternative methods, such as combining pantoprazole with docetaxel in metastatic castration-resistant prostate cancer, showed that although safe, not every autophagy-targeting strategy achieves the established efficacy benchmarks, highlighting the importance of accurate patient stratification

The efficiency and safety of methimazole and propylthiouracil in hyperthyroidism: A meta-analysis of randomized controlled trials

The authors would like to acknowledge the National Natural Science Foundation of China (81700055, R.T.), Natural Science Foundation of Jiangsu Province (BK20160229, R.T.), the Outstanding Talent Research Funding of Xuzhou Medical University (D2016021, R.T.), Postdoctoral foundation of Xuzhou Medical University (RC5052112, R.T.), National Natural Science Foundation of China (82241014, 82130002, Q.H.), Wuhan Science and Technology Bureau (2020020601012233, Q.H.), Supported by grants from the Ministry of Science and Technology of China (2021YFA0804803, K.S.) and the National Natural Science Foundation of China (81930012, 81730013, 81720108003, and 82130015, K.S.), the Research Start up Fund of Jining Medical University (Reference: 600791001, J.Y.)

In contrast, viruses and fungi represent lower-abundance components