To solve the challenge, numerous researchers devote to exploring the mechanism of PIPN, which are principally implicated in transporter overexpression (Sprowl et al., 2013), ROS upregulation (Leo et al., 2020), ion channel dysfunction (Descoeur et al., 2011), transient receptor potential (TRP) overexpression (Chukyo et al., 2018), inflammatory response (Janes et al., 2015), and so on
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In a study of 16 patients with chronic CIPN who were in remission and no longer receiving chemotherapy, 30-minute application of an 8% capsaicin patch to the feet resulted in lower patient-reported levels of pain, touch-evoked pain, and cold-evoked pain, with overall significant pain relief (Anand 2019)
Two major lipid peroxidation products, malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), increase with aging and contribute to the pathogenesis of AMD 63,64,65
Food Rev Int 38(sup1):286316 Dhineshkumar V, Ramasamy D (2016) Studies on development of yogurt flavoured with beetroot juice (Beta vulgaris L.)