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10.1016/j.bbi.2023.02.012 189 ZhuH.ZhangH.HouB.XuB.JiL.WuY

6.1 DNA methylation DNA methyltransferases (DNMTs) are key enzymes for DNA methylation [212], Goose deoxycholic acid and cholic acid in BAs can activate the nuclear receptor FXR and upregulate the expression of DNMTs, which can promote the alteration of the methylation status of the promoter region of ABCA1, LCAT, and other related genes that are beneficial to the synthesis and transport of HDL-C in the liver, and promote their expression, and HDL-C can transport cholesterol from the vascular wall to the liver for metabolism, which can reduce the cholesterol deposition in the vascular wall and reduce the AS [213]