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Diabetic nephropathy, another major complication, involves progressive kidney damage that can lead to proteinuria, decreased glomerular filtration rate (GFR), and eventually end-stage renal disease [182]

NGR1 administration also enhanced the co-localization of GFP-LC3 puncta and MitoTracker in rMC-1 cells, indicative of the increased formation of autophagosomes (Zhou et al., 2019)

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Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: relevance to angiogenesis

Together, these findings suggest that fungi in the Onygenales transitioned from saprophytes that digest plant materials to saprophytes that digest more limited plant materials and a wide range of animal proteins, and finally those that are major animal pathogens