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Frontiers in Endocrinology

The same method as before, we examined the transcription of Shh , Gli1 , Gli2 , and Gli3

P53 protein levels fluctuate across the day, driven by circadian control of MDM2 (the E3 ubiquitin ligase that targets p53 for degradation)

Proline introduces rigid kinks into peptide backbones, and proline-rich peptides typically show greater resistance to enzymatic degradation than linear peptides of comparable length