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Most cases (~90%) have no previous family history and hence are termed sporadic ALS (sALS). Specific environmental factors may increase the risk of developing ALS, including smoking, air pollution, agricultural and industrial pollutants, -N-methyl amino-L-alanine (BMAA) toxicity, and physical activity

Int J Obes 47:939947 Suez J, Cohen Y, Valds-Mas R, Mor U, Dori-Bachash M, Federici S, Zmora N, Leshem A, Heinemann M, Linevsky R et al (2022) Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance

The human skin-benefit evidence improved firmness, elasticity, and reduced fine lines comes almost entirely from topical creams and serums