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However, this has been ignored, while it has significant clinical importance

Nature (1978) 272(5656):8279

Exploratory evaluation of associations of Glx, GABA +, and GSH levels with changes in alcohol use (percent drinking days, drinks per drinking day) and PTSD symptoms (CAPS-5) were estimated via the addition of the main effects of, and all 2-way and 3-way interactions with, clinical variable difference scores (i.e., posttreatment-pretreatment), one per model