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Endurance training reduced oxidative damage to skeletal muscle and mitochondrial proteins in younger participants, whereas this effect was not observed in older individuals and appeared to be primarily regulated by protein degradationspecific mechanisms

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Initiation of the chain reaction of lipid peroxidation requires the spark provided by the reduction of Fe +3 to Fe +2 using a single electron provided by the O 2 - (superoxide anion radical) formed during oxidative respiration in mitochondria

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