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Inhibitors of bacterial enzymes that produce uremic metabolites, including iodomethylcholine, which inhibits bacterial TMA formation and lowered systemic creatinine levels, is a promising area of research

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By employing the safe and feasible gene-editing tool CRISPR/Cas9 to engineer T cells, this method can mitigate exhaustion-inducing signaling pathways, preserve antitumor activity, and increase the in vivo persistence of CAR-T cells, thereby further overcoming limitations in cancer therapy (Fig