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This pathway was also investigated in RAW264.7 cells, where IFN- production, accompanied by STAT-1 phosphorylation, was detected 6 hours after LPS exposure

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Disclosures: Vinay Jahagirdar: Nothing to Disclose, Waqas Rasheed: Nothing to Disclose, Hanna Blaney: Nothing to Disclose, Hassam Ali: Nothing to Disclose, Jasmohan Bajaj: Bausch: Grant/Research Support, Sequana: Grant/Research Support, Cosmo: Grant/Research Support, Grifols: Grant/Research Support 2290 SIMVASTATIN INEFFECTIVE IN IMPROVING HEPATOPULMONARY SYNDROME IN CIRRHOSIS PATIENTS (HEPSIM TRIAL) RESULTS OF A DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL [NCT05187715] Akhil Deshmukh 1 Shiv Kumar Sarin 1 Vishnu Girish 1 CHITRANSHU VASHISHTHA 1 Sukriti Baweja 1 Tushar Madke 1 Rahul khajuria 1 Harsh Tevethia 2 , 1 Institute Of Liver and Biliary Sciences, 2 INSTITUTE OF LIVER AND BILIARY SCIENCES(ILBS),NEW DELHI Background: Hepatopulmonary syndrome (HPS), marked by liver disease, intrapulmonary vascular dilatations, and abnormal oxygenation, causes significant morbidity and mortality