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Investigating synapse formation and function using human pluripotent stem cell-derived neurons

The integration of advanced imaging techniques with biomarker analysis promises to reveal new insights into ferroptosis dynamics in vivo, facilitating timely interventions to prevent or reduce brain injury

Some patients report subjective improvements in sleep quality or energy levels within the first treatment cycle, while potential effects on longevity markers require longer-term assessment

More specifically, GPX4 inhibits ferroptosis by reducing each PUFA-OOH to the corresponding PUFA-OH and oxidizing GSH (a reductive cofactor of GPX4) to GSSG (oxidized GSH) (Figure 1B) (Ma et al., 2022a)

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