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When ultrasound was used along with this developed formulation the effect in terms of reduced tumor growth was found to be 3.5 and 14.8 times more as compared to when ultrasound was not used and when only a physical mixture of drugs was used, respectively [280]

GHK stands for Glycyl-L-histidyl-L-lysine

Phosphorylation alters the electrostatic charge of its C-terminal domain, increasing its propensity for conformational changes, thus facilitating the transition from soluble monomers to insoluble oligomers and fibrils, effectively acting as a catalyst for the protein aggregation cascade [52]