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NNMT has been shown to be present in the human brain, a necessity for neurotoxicity, because charged compounds cannot cross the bloodbrain barrier (Williams & Ramsden, 2005)

In time, progression from NAFLD to fibrosis (scarring) and cirrhosis (scarring of the liver) can result in hepatorenal syndrome, a complication marked by severe kidney malfunction with reduced kidney blood flow and abdominal edema (ascites)