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Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast cancer cells with resistance to estrogen deprivation

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This process is accompanied by the break/reform of the coordination bond between Cu 2+ and one of the imidazolyls, leading to the redox reaction of Cu 2+ with electron gain or loss 15,16,23,24

It can be found in food sources, hydroxocobalamin vitamin B12 shots or as an intramuscular vitamin