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CT scans were assessed visually and using 3D nn-UNet to quantify parenchymal and intraventricular blood volumes

Procurement teams generally evaluate suppliers on documentation depth, RUO compliance, and analytical transparency

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Complicating this further: the regulatory picture shifted significantly between 2023 and 2025

Because unloading alone can reduce subchondral stress and pain and may influence BML appearance on MRI, the observed early improvements in VAS/KOOS/WOMAC and the 3-month MOAKS changes cannot be attributed specifically to BMAC