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The effects of the treatments on vascular tone were evaluated using rat thoracic aortic rings, as previously described [13]

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Its capacity for precise genome editing enables researchers to experimentally determine the roles of individual genes in biotic stress responses, moving beyond sequence-based predictions (Joshi et al., 2020

It is widely acknowledged that clinically approved therapies, such as statins and PCSK9 inhibitors, offer mechanistic insight into LDLR regulation by altering cholesterol metabolism and arresting LDLR lysosomal degradation