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While this methylation reaction was historically considered a relatively minor metabolic pathway for nicotinamide clearance, research over the past decade has revealed that NNMT plays a surprisingly important and previously underappreciated role in cellular energy metabolism, NAD+ homeostasis, adipocyte biology, and whole-body metabolic regulation

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In addition to offering a structural basis for the bifurcation of the receptors into their subfamilies, this is also likely to have a functional significance, potentially related to the specificity of receptor/G protein interaction

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daily for 5 days) protects the rat offspring from prenatal hyperhomocysteinemia [3]