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Well lets first look at what Iron does in the body

A few of the most significant contributors to NAD+ depletion include: CD38: An enzyme that breaks down NAD+ and becomes more active with age, especially in response to inflammation

Similarly, targeting NRF2 to upregulate phosphorylase kinase catalytic subunit 2 promotes ferritinophagy and mitochondrial stress-dependent ferroptosis, increasing radiosensitivity (123)