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Well studied epidemics of iodide-induced thyrotoxicosis occurred for example in Tasmania, Denmark, and India after the introduction of salt iodization and were clearly associated with multinodular goiters rather than typical GD (63-66)

For the first time, this study showed that chronic diquat exposure could reduce the oocyte quality as well as affect early embryo development, which is consistent with the previous report stated the malformations in diquat-treated mallard embryos (Sewalk et al., 2000)