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cytotoxicity data showed no toxicity to keratinocytes or fibroblasts across a six-log concentration range (0.0058 to 5800 micromolar) 3

Methods: SACRED is a phase III, prospective, multi-center, double-blind clinical trial (NCT03654053) that enrolled patients with compensated cirrhosis and clinically significant portal hypertension (CSPH), stratified upon concomitant use of nonselective beta-blockers, randomized enrollees 1:1 to simvastatin 40 mg/day versus placebo for up to 24 months at 11 Veterans Affairs Medical Centers in the United States

4ce, Supplementary Fig

Once their personalized treatment plan has been established and agreed upon, the injector will provide each patient with a quote during their personal consultation