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J Phys Chem Ref Data 18(3):11111229 Klopman G, Li JY, Wang S, Dimayuga M (1994) Computer automated Log P calculations based on an extended group contribution approach

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Meanwhile, the occurrence of depression involves complex molecular mechanisms related to dysfunction of the monoaminergic nervous system, abnormality of the hypothalamic pituitary adrenal axis, imbalance of calcium homeostasis and calcium signaling pathways, mitochondrial dysfunction, autophagy, cell apoptosis, and oxidative stress (Villa et al., 2018