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An inhibitor of oxidative phosphorylation exploits cancer vulnerability

These studies span dose ranges that encompass probable human exposures

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It is known as an antioxidant which gets rid of free radicals and also functions as a cofactor of gluta S-transferase, which aids in the absorption of amino acids and the production of molecules that work to respond to immunological and non-immunological stimuli

Pyridoxine has a history of successful use, at doses ranging from 50 to 800 mg per day, for the prevention and treatment of HFS caused by sorafenib (Nexavar), doxorubicin, 5-FU, docetaxel, or etoposide