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doi: 10.1016/j.addr.2015.07.007 146 SobiepanekAKurykAGarofaloMKumarSBaranJMusolfPet al

Comparing germ-free mice to conventionally grown (CONV-R) mice, it has been shown that the former had increased bone mass due to their changed immunological state, which includes lower pro-inflammatory cytokines, decreased CD4+ T cells, and fewer osteoclasts/precursors in the bone marrow (220)