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Bibcode:2009EnvMM..50..285S

Direct NLRP3 inhibitors like MCC950 and OLT1177 (Dapansutrile) have shown promise in reversing metabolic dysfunction in preclinical models [58]

At the same time, elevated tumor GSH can be exploited as a conditional trigger for prodrug activation, nanomedicine-based delivery, or metal-driven cytotoxicity, thereby converting a classical resistance factor into a therapeutically actionable vulnerability