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Understanding the mechanisms of -syn spread, as well as the impact of peripheral pathology on disease progression, is essential for the purpose of developing effective diagnostic and therapeutic strategies for PD

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Interestingly, alterations in lipid composition were observed in the raptor mutant group with total levels of cholesterol, ceramide, sphingomyelin, and glycosylceramide (critical component of myelinsee Section Reactive Oxygen Species) severely reduced in the whole spinal cord (Lebrun-Julien et al., Exogenous Modulators of OL Metabolism: From Drugs to Dietary Therapies Donepezil Promotes OL Differentiation and Increases Brain Glucose Metabolism The ability to exogenously regulate oligodendroglial metabolism has implications for a host of neurodegenerative diseases

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Ototoxicity: mechanisms of cochlear impairment and its prevention