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Acknowledgments The authors thank the academic editor and reviewers for their hard work and dedication

Interestingly, similar to CuPDTC, ZnPDTC also triggers proteasome inhibition and PARP1 cleavage (Milacic et al., 2008), raising questions about whether and how CuPDTC and ZnPDTC bind to the 20S proteasome

NRD.E1, an innovative non-opioid therapy for painful diabetic peripheral neuropathy-a randomized proof of concept study

Naunyn Schmiedebergs Arch Pharmacol 2014

Metabolic reprogramming and CRC metastasis: mechanistic insights and therapeutic implications Beyond its established role in therapy resistance, metabolic reprogramming is increasingly recognized as a critical driver of CRC metastasis, a major cause of poor patient prognosis [92, 93]