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Moreover, IF increases NAD + /NADH through altering cellular metabolic processes which leads to the Sirtuin proteins activation [18]

The activation of Nrf2 triggers the transcription of antioxidant and cytoprotective enzymes, including SOD, catalase, heme oxygenase 1, NAD(P) H, quinone oxidoreductase 1, and NAD(P) 36 , thereby enhancing the cells defense mechanisms

Furthermore, the AA, CYP, and PS + LPS models shared 9 upregulated and 30 downregulated genes, and the PS + LPS, CYP, and AA models had 9 upregulated and 5 downregulated genes in common

Crit Care Med 48:18551861 Mallat J, Pepy F, Lemyze M, Gasan G, Vangrunderbeeck N, Tronchon L, Vallet B, Thevenin D (2014) Central venous-to-arterial carbon dioxide partial pressure difference in early resuscitation from septic shock: a prospective observational study

PG analysed the data