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Huichalaf C, Perfitt TL, Kuperman A, Gooch R, Kovi RC, Brenneman KA, Chen X, Hirenallur-Shanthappa D, Ma T, Assaf BT, Pardo I, Franks T, Monarski L, Cheng T-W, Le K, Su C, Somanathan S, Whiteley LO, Bulawa C, Pregel MJ, Martelli A

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For instance, the downregulation of GPx4 has been correlated with the manifestation of radiation injury in various tissues including the intestine, hemopoietic system, lung, cardiovascular system, ovary, and skin of the murine model though enhancing the ferroptosis mode of cell death [67]

A study (Hambright et al., 2017) showed that GPX4-knockout AD mouse models exhibited reduced hippocampal and cortical neuronal proteins and increased LPO, which were reversed by the lipophilic antioxidant vitamin E

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