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169 Molecular mediators that drive organ crosstalk Interorgan crosstalk among the kidney, heart, brain, adipose tissue, liver, skeletal muscle, pancreas, and intestine plays a pivotal role in the development of insulin resistance and -cell dysfunction, which are central to the progression of diabetic complications

GPX4 activity assessment PC12 cells expressing GPX4-FLAG were pretreated with DA and FeCl 3 solution for 6 hours

Pyroptosis begins during the early stages of reperfusion and is responsible for acute IRI

However, a cavity on the capsid surface at an inter-protomer interface, where we previously reported extra electron density 7 , has recently been identified as potentially druggable, with micro-molar binding for a benzene-sulfonamide derivative 8