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Fatigue accompanied by anhedonia, sleep disturbances, or changes in appetite beyond those expected from the medication warrants evaluation for depression, potentially using validated screening tools like the PHQ-9

SAM S-adenosyl-L-[methyl-3H] methionine PRMT3 activity assay A radiometric assay was performed by RBC using 100 M-5 nM SAH as an inhibitor positive control