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Notably, endogenous GHK-Cu levels in human plasma are age-dependent, dropping from ~200 ng/mL at age 20 to below 80 ng/mL after age 60

[DOI] [PubMed] [Google Scholar] 28.Zhu X, Yu Z, Feng L, et al

(28) revealed a significant reduction in the concentrations of Bub1 and BubR1 in the oocytes of women over the age of 37, as compared to those in women under the age of 32