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Key signaling pathway proteins such as focal adhesion kinase-1 (FAK1), DNA methyltransferase 3B (DNMT3B), latent TGF- binding proteins 1 (LTBP1), and hypoxia-inducible factor 1-alpha (HIF1) are affected by SNO modification, influencing protein activity and ultimately disrupting cell viability

When those same patients transition to a properly formulated injectable protocol, the clinical picture changes within weeks

Nature 545 , 299304 (2017)

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