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Although dabigatran is mainly used in patients with cardiovascular disease, atrial fibrillation, or stroke, and the pharmacokinetic and pharmacodynamic properties of the healthy population differ from those of patients, the pharmacokinetic parameters of healthy subjects are more stable and can more clearly reflect the absorption, distribution, metabolism, and excretion characteristics of the drug, thus providing reliable baseline data for subsequent patient studies to validate the efficacy and safety of dabigatran in specific disease states

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Dominik Malekinusic, Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb 10 000, Croatia

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling