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Methods In this study, we design a two-in-one ferroptosis-inducing nanoplatform using iron-based metal-organic framework (MOF) that combines iron supply and GPX4 deactivation by loading the small molecule buthionine sulfoxide amine (BSO) to block de novo GSH biosynthesis, which can achieve sustainable GSH elimination and dual ferroptosis amplification

Vin ung Glutathione 600 Dr Lacir chnh hng hin ang c bn ti Nh thuc Dc s Lu Vn Hong, gi sn phm c th c cp nhp ti u trang

Statements Author contributions BZ: Writing original draft, Data curation, Formal Analysis, Conceptualization

Heavy Metals Test Measure blood levels of mercury, lead, cadmium and arsenic markers relevant to heavy metal exposure

Rotating injection sites prevents tissue irritation and ensures consistent absorption