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Figure 2 Recent studies have shown that the structure of DNMT3bs methyltransferase domain is more susceptible to mutations associated with ICF syndrome compared to its complex with DNMT3L (85)

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Autophagy is required for the activation of NF

, paracetamol preferentially inhibited brain cyclooxygenases (32)), thereby generalized convulsions, particularly presenting brain tissue's high susceptibility to oxidative stress, leaving the glutathione in the brain defenseless to depletion by paracetamol (4, 5), unless BPC 157 was applied