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In chronic kidney disease, loss of kidney epithelial cells leads to glomerulosclerosis and tubular atrophy, whereas interstitial inflammation and fibrosis result from an excess of leukocytes and myofibroblasts

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The study compiled fifteen epidemiological research papers, five of which focused on shift work employment, and identified BMAL1, BMAL2, CLOCK, neuronal PAS domain protein 2 (NPAS2), CRY1, CRY2, PER1, PER3, and TIMELESS as potential risk variants for breast cancer [28]