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It is classified into compensated and decompensated stages based on the disease's progression

harbour mutant APP, PS1 and tau) and PDAPP-J20 (expressing Swedish-Indiana APP mutations)

For example, inhibition of ATR leads to accumulation of unrepaired cytoplasmic DNA, activates cGAS-STING pathway and induces type I interferon secretion, which enhances T cell infiltration and antitumor immunity (200,201)