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The disc is loaded with compression or shear/distraction, and nucleus pulposus tissue is lost as it herniates either through the ruptured annulus or failed annulus-endplate interface (disc injury type B1) or through the fractures lines of the endplate (disc injury type B3)

CO2 lasers carry higher risks for patients with darker skin tones due to their mechanism of action targeting pigment

The intestinal barrier is primarily maintained by tight junctions (TJs) between epithelial cells, which regulate intestinal permeability and prevent the invasion of pathogens and harmful substances into the submucosal layer

Shi, B., Abrams, M

Regeneration of intervertebral discs in a rat disc degeneration model by implanted adipose-tissue-derived stromal cells