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American Society of Health-System Pharmacists (ASHP)

Interestingly, noe1 plants exhibited an increase of H 2 O 2 in their leaves, which consequently promoted NO production via activation of nitrate reductase

This beneficial effect is due to the contribution of SCFAs in modulating energy metabolism, regulating inflammation and immune response, and inhibiting oxidative stress and mitochondrial damage

The oxidation of Trx 1 causes its detachment from its binding partner apoptosis signal-regulating kinase 1 (ASK1), resulting in ASK1 activation by phosphorylation55

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