Importantly, therapeutic manipulation of any single node in this circuit yields highly variable outcomes that depend on tumor type, microenvironmental pressures, therapy modality (ICB versus ACT), and timing of intervention
Secondary disorders are only a manifestation of an underlying CNS disease
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Heme and iron metabolism Another critical function of the NRF2 antioxidant program is the regulation of iron metabolism
Dreyer BA, Amer T, Fraser M
