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Protein carbonyl assay RWPE-1, LNCaP, COS-7, and COS-7-OPH cells were grown in 25 cm 3 cell culture flasks to 80% confluence

Simultaneously, studies using molecular biology detection and pharmacological intervention confirmed that heat stress triggers cPLA2 activation and increases the level of its metabolite arachidonic acid to participate in lipid peroxidation in the mouse heatstroke model, further promoting the occurrence of ferroptosis, thereby aggravating the progression of ALI after heat stress [48]

doi: 10.1172/JCI143774 238 SencioVBarthelemyATavaresLPMaChadoMGSoulardDCuinatCet al

Patient selection should be improved to reduce risk for short-term complications after which lavage could still be a valuable treatment option

Winter L, Pawlowsky L, Marcinek A, Brauchle B, Muth A, Kazerani M, Petrera A, Kischel R, Emhardt AJ, Rothenberg-Thurley M, Dufour AM, Spiekermann K, Andreeff M , Daver N, Buecklein VL, and Subklewe M