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In ALD, neutrophils are recruited to the liver and release IL-8 through autocrine and paracrine mechanisms, acting as a chemotactic factor that attracts additional neutrophils to the liver, thus perpetuating a vicious cycle [75]

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Further evidence was provided by a time-course western blot analysis of striatal GSTO2 and TH protein levels, showing GSTO2 upregulation before TH increase by 1 month (Figs