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elegans ortholog Skn-1 that upregulate a plethora of phase II detoxification genes 47,48,49,50,51

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During tryptophan catabolism, tryptophan is further metabolized to L-kynurenine (Kyn) via indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and TDO to produce N-formylkynurenine