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Can Vet J 44:982983 Toscano M, de Vecchi E, Rodighiero V, Drago L (2013) Microbiological and genetic identification of some probiotics proposed for medical use in 2011

Aggregation causes peptides to clump and lose biological activity

This means it wont break down and become ineffective if exposed to air

Genetic studies strongly support the involvement of autophagy machinery in SLE susceptibility, with GWAS identifying risk polymorphisms in ATG5, ATG7, and MTMR3